Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway
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چکیده
منابع مشابه
Dihydroartemisinin induces apoptosis by a Bak-dependent intrinsic pathway.
The sesquiterpene lactone dihydroartemisinin (DHA), a semisynthetic derivative of the herbal antimalaria drug artemisinin, is cytotoxic to human tumor cells. Treatment of Jurkat T-lymphoma cells with DHA induced a breakdown of the mitochondrial transmembrane potential, release of cytochrome c, activation of caspases, and DNA fragmentation indicative of apoptosis induction. Although the absence ...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2010
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-10-0051